منابع مشابه
Doctor David Livingstone
An anatomical exposition of the structure of the human body, trans. Lords of the Admiralty for the effectual cure of such seamen belonging to the Navy as may have ruptures, London, 1734. The paper, read on the occasion of the centenary of David Livingstone's death in what is now the independent African country of Zambia, was divided into three sections. The first part was devoted to Livingstone...
متن کاملDmd058347 1873..1880
Historically, since the metabolism of administered peptide/protein drugs (“biotherapeutics”) has been expected to undergo predictable pathways similar to endogenous proteins, comprehensive biotherapeutic metabolism studies have not been widely reported in the literature. However, since biotherapeutics have rapidly evolved into an impressive array of eclectic modalities, there has been a shift t...
متن کاملDdh188 1803..1813
Polyglutamine diseases are characterized by neuronal intranuclear inclusions (NIIs) of expanded polyglutamine proteins, indicating the failure of protein degradation. UBB, an aberrant form of ubiquitin, is a substrate and inhibitor of the proteasome, and was previously reported to accumulate in Alzheimer disease and other tauopathies. Here, we show accumulation of UBB in the NIIs and the cytopl...
متن کاملDev101428 1805..1813
Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in the brain, with important consequences on behavior and neuronal fun...
متن کاملAlexis Carrel (1873-1944)
Alexis Carrel [5] was a doctor and researcher who studied tissue cultures. He continued Ross Granville Harrison?s research and produced many improvements in the field of tissue culture and surgery. He was the recipient of the 1912 Nobel Prize in Physiology or Medicine [6] for his development of surgical techniques to repair blood vessels. Carrel was born on 28 June 1873 in Sainte-Foy-les-Lyon, ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1973
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5860.323